Trifluoroacetic acid → 1-((R)-2-amino-propionyl)-azetidine-3-carbonitrile trifluoroacetate

HRID 246101노트

반응식

HRID 246101 반응식
C(OC(=O)[NH:7][C@H:8]([CH3:17])[C:9]([N:11]1[CH2:14][CH:13]([C:15]#[N:16])[CH2:12]1)=[O:10])(C)(C)C.[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22]>ClCCl>[F:19][C:20]([F:25])([F:24])[C:21]([OH:23])=[O:22].[NH2:7][C@H:8]([CH3:17])[C:9]([N:11]1[CH2:12][CH:13]([C:15]#[N:16])[CH2:14]1)=[O:10]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67386290HCID 67386290, 화합물

생성물 1

HCID 673864061-((R)-2-amino-propionyl)-azetidine-3-carbonitrile trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

[(R)-2-(3-cyanoazetidin-1-yl)-1-methyl-2-oxo-ethyl]-carbamic acid tert-butyl ester (47 mg, 0.185 mmol) was dissolved in dichloromethane (1 ml) and cooled in an ice bath. Trifluoroacetic acid (0.5 ml) was slowly added and the reaction was stirred at room temperature for 2 h then evaporated and dried under high vacuum to afford 1-((R)-2-amino-propionyl)-azetidine-3-carbonitrile trifluoroacetate which was used without further purification.

후처리

  1. temperaturecooled in an ice bath
  2. customthen evaporated
  3. customdried under high vacuum

출처 및 근거

ORD 기록
ord-75e169a338254f73aa75681bbc65fe9a
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658646B2

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