4-Nitrophenyl chloroformate → Benzyl 4-(3-chlorophenyl)-3-(3,3-diphenylpropylcarbamoyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

HRID 24612노트

반응식

HRID 24612 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13]([C:14]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:15])=[C:12]([CH3:24])[NH:11][C:10]([O:25]C)=[N:9]2)[CH:5]=[CH:6][CH:7]=1.ClC(O[C:31]1[CH:36]=[CH:35][C:34]([N+]([O-])=O)=[CH:33][CH:32]=1)=O.[C:40](=[O:43])([O-])O.[Na+]>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[C:13]([C:14]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:15])=[C:12]([CH3:24])[NH:11][C:10](=[O:25])[N:9]2[C:40](=[O:43])[NH:11][CH2:12][CH2:13][CH:8]([C:31]2[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=2)[C:4]2[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=2)[CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 821294-Nitrophenyl chloroformateHCID 516892Sodium BicarbonateHCID 22570191Benzyl 4-(3-chlorophenyl)-2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylate

생성물 1

HCID 15546109Benzyl 4-(3-chlorophenyl)-3-(3,3-diphenylpropylcarbamoyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

558 mg (1.50 mmol) of benzyl 4-(3-chlorophenyl)-2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylate and 364 mg (1.81 mmol) of p-nitrophenyl chloroformate were dissolved in 10 ml of dichloromethane. 1 ml of saturated sodium hydrogencarbonate solution was added to the obtained solution at 0° C., and they were stirred at room temperature for 24 hours. The reaction mixture was diluted with dichloromethane and then washed with water and saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The product was washed with ether and then dried under reduced pressure to obtain the title compound.

후처리

  1. washwashed with water and saturated aqueous sodium chloride solution
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure
  4. washThe product was washed with ether
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-83ed804ac4aa4f27bcc24ff251f42e34
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855716B2

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