Trifluoroacetic acid → (R)-3-amino-2-methyl-propionitrile trifluoroacetate
반응식
C(OC(=O)[NH:7][CH2:8][C@H:9]([C:11]#[N:12])[CH3:10])(C)(C)C.[F:14][C:15]([F:20])([F:19])[C:16]([OH:18])=[O:17]>ClCCl>[F:14][C:15]([F:20])([F:19])[C:16]([OH:18])=[O:17].[NH2:12][CH2:11][C@@H:9]([CH3:10])[C:8]#[N:7]참가 물질
4
실험 절차
((R)-2-Cyano-2-methyl-ethyl)-carbamic acid tert-butyl ester (42 mg, 0.23 mmol) was dissolved in dichloromethane (1.2 ml) and cooled in an ice bath. Trifluoroacetic acid (0.7 ml) was slowly added and the reaction was stirred at room temperature for 3 h then evaporated and dried under high vacuum to afford (R)-3-amino-2-methyl-propionitrile trifluoroacetate which was used without further purification.
후처리
- temperaturecooled in an ice bath
- customthen evaporated
- customdried under high vacuum
출처 및 근거
- ORD 기록
- ord-18b095b4312b412a98cb285f2a192129
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08658646B2
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