Trifluoroacetic acid → (S)-(Tetrahydro-pyran-3-yl)amine trifluoroacetate

HRID 246132노트

반응식

HRID 246132 반응식
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][CH2:11][O:10][CH2:9]1)(C)(C)C.[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18]>ClCCl>[F:15][C:16]([F:21])([F:20])[C:17]([OH:19])=[O:18].[O:10]1[CH2:11][CH2:12][CH2:13][C@H:8]([NH2:7])[CH2:9]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67324694(S)-tert-butyl tetrahydro-2H-pyran-3-ylcarbamate

생성물 1

HCID 71280724(S)-(Tetrahydro-pyran-3-yl)amine trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

(S)-(Tetrahydro-pyran-3-yl)-carbamic acid tert-butyl ester (42 mg, 0.21 mmol) was dissolved in dichloromethane (2.2 ml) and cooled in an ice bath. Trifluoroacetic acid (1.2 ml) was slowly added and the reaction was stirred at room temperature for 3 h then evaporated and dried under high vacuum to afford (S)-(Tetrahydro-pyran-3-yl)amine trifluoroacetate which was used without further purification.

후처리

  1. temperaturecooled in an ice bath
  2. customthen evaporated
  3. customdried under high vacuum

출처 및 근거

ORD 기록
ord-fff9c8c54d0e477aaaac4c38aa4d05de
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658646B2

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