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Ethyl Acetate → 4-(3-Chlorophenyl)-3-(3,3-diphenylpropylcarbamoyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

HRID 24614
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인쇄 미리보기

반응식

HRID 24614 반응식
C(OCC)(=O)C.[Cl:7][C:8]1[CH:9]=[C:10]([CH:14]2[C:19]([C:20]([O:22]CC3C=CC=CC=3)=[O:21])=[C:18]([CH3:30])[NH:17][C:16](=[O:31])[N:15]2[C:32](=[O:49])[NH:33][CH2:34][CH2:35][CH:36]([C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)[C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH:11]=[CH:12][CH:13]=1>[H][H].[Pd]>[Cl:7][C:8]1[CH:9]=[C:10]([CH:14]2[C:19]([C:20]([OH:22])=[O:21])=[C:18]([CH3:30])[NH:17][C:16](=[O:31])[N:15]2[C:32](=[O:49])[NH:33][CH2:34][CH2:35][CH:36]([C:43]2[CH:44]=[CH:45][CH:46]=[CH:47][CH:48]=2)[C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH:11]=[CH:12][CH:13]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 8857Ethyl AcetateHCID 15546109Benzyl 4-(3-chlorophenyl)-3-(3,3-diphenylpropylcarbamoyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

생성물 1

HCID 225701354-(3-Chlorophenyl)-3-(3,3-diphenylpropylcarbamoyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 178418361
HCID 178418361, 화합물
용매

실험 절차

10 ml of ethyl acetate was added to a mixture of 141 mg (0.237 mmol) of benzyl 4-(3-chlorophenyl)-3-(3,3-diphenylpropylcarbamoyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate and a catalytic amount of 10% palladium/carbon, and they were stirred at room temperature in hydrogen atmosphere under normal pressure overnight. The catalyst was filtered out, and the obtained filtrate was concentrated under reduced pressure. The residue was washed with hexane/ethyl acetate (1/1) and then dried under reduced pressure to obtain the title compound.

후처리

  1. filtrationThe catalyst was filtered out
  2. concentrationthe obtained filtrate was concentrated under reduced pressure
  3. washThe residue was washed with hexane/ethyl acetate (1/1)
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-cd287b5f97f346d58ec07aa85d639907
출처 데이터셋
uspto-grants-2005_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06855716B2

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