Trifluoroacetic acid → HCID 71280181, 화합물

HRID 246280노트

반응식

HRID 246280 반응식
C(OC(=O)[NH:7][C:8]1([C:12]([OH:15])([CH3:14])[CH3:13])[CH2:11][CH2:10][CH2:9]1)(C)(C)C.[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20]>ClCCl>[F:17][C:18]([F:23])([F:22])[C:19]([OH:21])=[O:20].[NH2:7][C:8]1([C:12]([OH:15])([CH3:14])[CH3:13])[CH2:11][CH2:10][CH2:9]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 712805461426423-60-0

생성물 1

HCID 71280181HCID 71280181, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In a 25 ml round-bottomed flask, [1-(1-hydroxy-1-methyl-ethyl)-cyclobutyl]-carbamic acid tert-butyl ester (150 mg, 0.65 mmol) was dissolved in dichloromethane (3.8 ml) and trifluoroacetic acid (1.5 ml, 19.5 mmol) was slowly added. The pale yellow reaction mixture was stirred at room temperature for 2.5 h then concentrated to give 2-(1-amino-cyclobutyl)-propan-2-ol trifluoroacetate as a light brown oil which was used without further purification.

후처리

  1. concentrationthen concentrated

출처 및 근거

ORD 기록
ord-0f8391747d01459a998776a704523355
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08658646B2

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