Potassium Carbonate → N-(2,6-Dichlorobenzoyl)-4-[2-[N-(tert-butyl)sulfamoyl]phenyl]-L-phenylalanine methyl ester

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	Boronic acid, B-(2-(((1,1-dimethylethyl)amino)sulfonyl)phenyl)-	HCID 4997616	—
반응물	N-(2,6-dichlorobenzoyl)-4-bromo-L-phenylalanine methyl ester	HCID 54284267	—
촉매	HCID 178418397	HCID 178418397	—
용매	Water	HCID 962	—
용매	1,2-Dimethoxyethane	HCID 8071	—
용매	Ethyl Acetate	HCID 8857	—
생성물	N-(2,6-Dichlorobenzoyl)-4-[2-[N-(tert-butyl)sulfamoyl]phenyl]-L-phenylalanine methyl ester	HCID 53906758	76.5%

반응 조건

온도	80 °C

반응 단계

2-[N-(tert-Butyl)sulfamoyl]benzeneboronic acid (0.4 g) was dissolved in DME (10 mL). To this solution was added K2CO3 (0.1 g), N-(2,6-dichlorobenzoyl)-4-bromo-L-phenylalanine methyl ester (0.1 g), Pd(Ph3P)4 (0.1 g) and water (0.2 mL). The mixture was heated at 80° C. overnight. After cooling, EtOAc and water were added to the mixture. The EtOAc phase was dried (MgSO4), filtered and evaporated. The residue was purified by flash column chromatography (silica gel; eluent: EtOAc/hexanes 1:2) to give 100 mg of the title compound. ESMS: m/z 585 ([M+Na]+).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06855843B2
출처 데이터셋	uspto-grants-2005_02
ORD ID	ord-3fbb1750900f439ba20a4652ef70f839
출처 메모	uspto-grants-2005_02