Sulfuric Acid → Benzylsulfamic acid

HRID 246829노트

반응식

HRID 246829 반응식
[CH2:1]([N:8]=C=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:11](=O)(=[O:14])([OH:13])[OH:12]>[N+](C)([O-])=O>[CH2:1]([NH:8][S:11](=[O:13])(=[O:12])[OH:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 76639Benzyl isocyanate

생성물 1

HCID 12649342Benzylsulfamic acid

시약·촉매·용매 1

HCID 6375Nitromethane용매

실험 절차

Benzylisocyanate (13.3 g) is added dropwise to a stirred mixture of nitromethane (160 ml) and 15% fuming sulfuric acid (5.4 ml) at about 10° C. The reaction mixture is refluxed for about one hour, cooled to RT and the solid filtered and washed with nitromethane. The solid is suspended in ether, filtered, dried and used as a crude solid in the next step.

후처리

  1. temperatureThe reaction mixture is refluxed for about one hour
  2. filtrationthe solid filtered
  3. washwashed with nitromethane
  4. filtrationfiltered
  5. customdried

출처 및 근거

ORD 기록
ord-a2a22afeb7bc47b199b85f68f22f7a67
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04704388

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