Phosphorus pentachloride → Benzylsulfamyl chloride

HRID 246830노트

반응식

HRID 246830 반응식
[CH2:1]([NH:8][S:9](=[O:12])(=O)[OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:14]>C1(C)C=CC=CC=1>[CH2:1]([NH:8][S:9]([Cl:14])(=[O:12])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24819Phosphorus pentachlorideHCID 12649342Benzylsulfamic acid

생성물 1

HCID 13529095Benzylsulfamyl chloride

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A stirred mixture of benzylsulfamic acid (73 g), PCl5 (81 g) in toluene (540 ml) is heated to 40°-50° C. for one hour and refluxed for about 3 hours. The cooled mixture is filtered through Celite and the filtrate concentrated in vacuo to remove the toluene affording the desired product as a liquid.

후처리

  1. temperatureis heated to 40°-50° C. for one hour
  2. temperaturerefluxed for about 3 hours
  3. filtrationThe cooled mixture is filtered through Celite
  4. concentrationthe filtrate concentrated in vacuo
  5. customto remove the toluene affording the desired product as a liquid

출처 및 근거

ORD 기록
ord-616e6714301d4dfa87f2652f15a6082a
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04704388

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