Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Butanedione → 3-Hydroxy-1-phenylbutan-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Butanedione | HCID 650 | — |
| 반응물 | 3-Hydroxy-3-phenylbutan-2-one | HCID 233220 | — |
| 반응물 | HCID 178418255 | HCID 178418255 | — |
| 생성물 | 3-Hydroxy-1-phenylbutan-2-one | HCID 13600679 | 30% |
반응 단계
The preparation of 3-hydroxy-3-phenylbutan-2-one by reaction of 2,3-butanedione with an appropriate Grignard reagent is described in an article by Lapkin and Golovkova in Zuhr. Obshchei Khim (J. Gen. Chem.) 19, 701-6 (1949) and abstracted in Chemical Abstracts 44, 1057h (1950). The reaction of biacetyl with phenylmagnesium bromide (31.4 g) gave 30% methylphenylacetylcarbinol. The reaction conditions are not specifically described but earlier in the abstract the solvent used was diethyl ether and the reactants were heated for 10 hours. The preparation is also referred to in Beilsteins Handbook (1969) at page 458.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04704475 |
| 출처 데이터셋 | uspto-grants-1987_11 |
| ORD ID | ord-ce3aeadc03d448cd93a837df304f02ba |
| 출처 메모 | uspto-grants-1987_11 |