Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 3,5-Dimethoxybenzyl tert-butyldiphenylsilyl ether
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | 3,5-Dimethoxybenzyl alcohol | HCID 69718 | — |
| 반응물 | tert-Butyldiphenylchlorosilane | HCID 94078 | — |
| 생성물 | 3,5-Dimethoxybenzyl tert-butyldiphenylsilyl ether | HCID 22571883 | 87.9% |
반응 단계
A mixture of 3,5-dimethoxybenzyl alcohol (4.0 g), t-butyl-diphenylsilyl chloride (6.54 g) and imidazole (3.28 g) in DML (60 mL) was stirred at room temperature for 24 h. DMF was evaporated and the residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20%) to yield 8.5 g of 3,5-dimethoxy-1-[(t-butyldiphenylsilyloxy)methyl]benzene. ESMS: m/z 407 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855843B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-4b8ebf0f858447abb7f17f0abe7bc319 |
| 출처 메모 | uspto-grants-2005_02 |