Bromochloromethane → 4-(Chloromethylthio) benzyl alcohol

HRID 247064

반응식

HRID 247064 반응식
[SH:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][CH:3]=1.Br[CH2:11][Cl:12].C(N(CC)CC)C>>[Cl:12][CH2:11][S:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][OH:7])=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 6333BromochloromethaneHCID 8471TriethylamineHCID 4677905(4-Sulfanylphenyl)methanol

생성물 1

HCID 538676354-(Chloromethylthio) benzyl alcohol

실험 절차

4-Mercaptobenzyl alcohol (see J.Chem.Soc 1963 p 1947) (5.0 mmol) was dissolved in bromochloromethane (100 mmol) and triethylamine (5 mmol) added dropwise. The resultant mixture was stirred for 1 hour at room temperature, washed with water and the dried (MgSO4) organic solution evaporated to leave the product. Yield 0.94g (95%) 1H NMR (CDCl3, δ): 2.03 (OH), 4.65 (CH2O), 4.90 (CH2S), 7.1-7.4 (Ph). The product needed no further purification for use in Example 33.

후처리

  1. washwashed with water
  2. dry with materialthe dried (MgSO4) organic solution
  3. customevaporated
  4. customto leave the product
  5. customno further purification for use in Example 33

출처 및 근거

ORD 기록
ord-0b078959122b4c1ead27ab20e7cc57cb
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04705791

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