3-Thiocresol → 1-(3-Tolylsulfenyl)methyl-5-chloropyrimidin-2-one

HRID 247084

반응식

HRID 247084 반응식
Cl[CH2:2][N:3]1[CH:8]=[C:7]([Cl:9])[CH:6]=[N:5][C:4]1=[O:10].[CH3:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([SH:18])[CH:13]=1.C(N(CC)CC)C>>[C:12]1([CH3:11])[CH:17]=[CH:16][CH:15]=[C:14]([S:18][CH2:2][N:3]2[CH:8]=[C:7]([Cl:9])[CH:6]=[N:5][C:4]2=[O:10])[CH:13]=1

참가 물질

4

반응물 3

HCID 79303-ThiocresolHCID 8471TriethylamineHCID 201613341-Chloromethyl-5-chloropyrimidin-2-one

생성물 1

HCID 135300961-(3-Tolylsulfenyl)methyl-5-chloropyrimidin-2-one

반응 조건

온도
40 °C

실험 절차

1-Chloromethyl-5-chloropyrimidin-2-one (see Preparation 15) (1.0 mmol) was added to a mixture of m-thiocresol (1.0 mmol) and triethylamine (1.0 mmol). The mixture was stirred at room temperature for 20 mins and at 40° C. for 20 mins before the solvent was distilled off and the residue triturated with water, extracted into chloroform, dried (MgSO4) and evaporated. The residue was washed with cold acetone (1 ml). The insoluble product was identical with an authentic sample prepared as described in Example 14. Yield: 60 mg, 22%.

후처리

  1. distillationwas distilled off
  2. customthe residue triturated with water
  3. extractionextracted into chloroform
  4. dry with materialdried (MgSO4)
  5. customevaporated
  6. washThe residue was washed with cold acetone (1 ml)
  7. customprepared

출처 및 근거

ORD 기록
ord-406721d3280f4895bc58b724e66e5d4b
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04705791

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