1-(Cyanomethyl)-3,5-dimethoxybenzene → 1-Bromo-2,4-dimethoxy-6-cyanobenzene

HRID 24709노트

반응식

HRID 24709 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:11][CH3:12])[CH:10]=1)[C:6]#[N:7].[Br-:13].[Br-].[Br-].[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1.[NH+]1C=CC=CC=1>C(Cl)Cl>[Br:13][C:4]1[C:5]([C:6]#[N:7])=[CH:8][C:9]([O:11][CH3:12])=[CH:10][C:3]=1[O:2][CH3:1]

참가 물질

4

반응물 2

HCID 294821-(Cyanomethyl)-3,5-dimethoxybenzeneHCID 21124087Pyridiniumtribromide

생성물 1

HCID 225718291-Bromo-2,4-dimethoxy-6-cyanobenzene수율 89.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 3,5-dimethoxybenzonitrile (2 g) in CH2Cl2 (100 mL) was added pyridinium tribromide (4 g). The mixture was stirred for 24 h at room temperature then washed successively with aqueous NaHCO3, water and brine, dried (MgSO4) filtered and evaporated. The residue was crystallized from CH2Cl2 and hexane to yield the title compound (1.8 g).

후처리

  1. washthen washed successively with aqueous NaHCO3, water and brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. customevaporated
  5. customThe residue was crystallized from CH2Cl2 and hexane

출처 및 근거

ORD 기록
ord-27cbedddaa434946b43587b7aee9fe3e
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855843B2

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