Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Nitrobenzaldehyde → 5-Acetyl-1,4-dihydro-2,6-dimethyl-3-(3-chloromethyl-1,2,4-oxadiazol-5-yl)-4-(3-nitrophenyl)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Nitrobenzaldehyde | HCID 7449 | — |
| 반응물 | 4-Amino-3-penten-2-one | HCID 136873 | — |
| 반응물 | 5-Acetonyl-3-chloromethyl-1,2,4-oxadiazole | HCID 13824705 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 5-Acetyl-1,4-dihydro-2,6-dimethyl-3-(3-chloromethyl-1,2,4-oxadiazol-5-yl)-4-(3-nitrophenyl)pyridine | HCID 135833423 | 67.1% |
반응 단계
A stirred solution of 0.53 g of 5-acetonyl-3-chloromethyl-1,2,4-oxadiazole, 0.46 g of 3-nitrobenzaldehyde and 0.30 g of 2-amino-4-oxo-2-pentene in 4 ml of isopropyl alcohol was heated under reflux for 14 hours. The reaction mixture was concentrated in vacuo and the residue was chromatographed on silica gel using benzene-acetonitrile (15:1) as eluent to give 0.79 g of 5-acetyl-1,4-dihydro-2,6-dimethyl-3-(3-chloromethyl-1,2,4-oxadiazol-5-yl)-4-(3-nitrophenyl)pyridine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04705786 |
| 출처 데이터셋 | uspto-grants-1987_11 |
| ORD ID | ord-3a3cdfe57e434f88a507f35d90df3dfe |
| 출처 메모 | uspto-grants-1987_11 |