Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,5-Dimethoxytetrahydrofuran → 2-Chloro-4-(1-pyrrolyl)benzoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,5-Dimethoxytetrahydrofuran | HCID 79098 | — |
| 반응물 | Methyl 4-Amino-2-chlorobenzoate | HCID 11839197 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Chloro-4-(1-pyrrolyl)benzoic acid methyl ester | HCID 4763735 | — |
반응 단계
A mixture of 4-amino-2-chlorobenzoic acid methyl ester (0.46 g) and 2,5-dimethoxytetrahydrofuran (0.33 mL) in AcOH (16 mL) was heated under reflux for 2 h. The mixture was cooled to room temperature, diluted with water and extracted with EtOAc. The extract was washed with satd. NaHCO3 and brine, dried (MgSO4), filtered and evaporated. The residue was purified by column chromatography (silica gel; eluent: hexane/EtOAc 5/1) to yield 0.48 g of 2-chloro-4-(1-pyrrolyl)benzoic acid methyl ester. ESMS: m/z 236 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06855843B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-7d9c216325c049cd98f689b70dd37e81 |
| 출처 메모 | uspto-grants-2005_02 |