4-Fluorobenzoic Acid → 4-Fluorobenzoic acid, 3-fluorophenyl ester

HRID 247186

반응식

HRID 247186 반응식
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1>COCCOCCOCCOCCOC>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][C:4]2[CH:5]=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=2)=[O:7])=[CH:4][CH:3]=1

참가 물질

3

반응물 1

HCID 99734-Fluorobenzoic Acid

생성물 1

HCID 141493914-Fluorobenzoic acid, 3-fluorophenyl ester수율 1.1%

시약·촉매·용매 1

HCID 8925Tetraglyme용매

반응 조건

온도
240 °C

실험 절차

A 25-ml Kjeldahl flask fitted with an air-cooling line was charged with 1.4 g of p-flurobenzoic acid, 0.976 g of cupric hydroxide, and 3 ml of tetraglyme as solvent, after which it was heated at 240° C. over an oil bath. This temperature was maintained for 60 minutes. After cooling, the reaction mixture was eluted with diethyl ether followed by filtration using Celite. the resulting filtrate was then submitted to column chromatography (solid phase: silica gel, developing solvent: hexane→methylene chloride) to give 0.013 g of m-fluorophenyl p-fluorobenzoate.

후처리

  1. customA 25-ml Kjeldahl flask fitted with an air-cooling line
  2. temperatureThis temperature was maintained for 60 minutes
  3. temperatureAfter cooling
  4. washthe reaction mixture was eluted with diethyl ether
  5. filtrationfollowed by filtration

출처 및 근거

ORD 기록
ord-e7eec9de80b243ba891dc68229b2903d
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04705884

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