4-Fluorobenzoic Acid → 4-Fluorobenzoic acid, 3-fluorophenyl ester
반응식
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1>COCCOCCOCCOCCOC>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][C:4]2[CH:5]=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=2)=[O:7])=[CH:4][CH:3]=1참가 물질
3
반응 조건
- 온도
- 240 °C
실험 절차
A 25-ml Kjeldahl flask fitted with an air-cooling line was charged with 1.4 g of p-flurobenzoic acid, 0.976 g of cupric hydroxide, and 3 ml of tetraglyme as solvent, after which it was heated at 240° C. over an oil bath. This temperature was maintained for 60 minutes. After cooling, the reaction mixture was eluted with diethyl ether followed by filtration using Celite. the resulting filtrate was then submitted to column chromatography (solid phase: silica gel, developing solvent: hexane→methylene chloride) to give 0.013 g of m-fluorophenyl p-fluorobenzoate.
후처리
- customA 25-ml Kjeldahl flask fitted with an air-cooling line
- temperatureThis temperature was maintained for 60 minutes
- temperatureAfter cooling
- washthe reaction mixture was eluted with diethyl ether
- filtrationfollowed by filtration
출처 및 근거
- ORD 기록
- ord-e7eec9de80b243ba891dc68229b2903d
- 출처 데이터셋
- uspto-grants-1987_11
- 특허 번호
- US04705884
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