참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2-Chloronicotinic acid | HCID 76258 | — |
| 반응물 | 3-Azetidinol, 1-cyclohexyl- | HCID 98585 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Sodium 2-[(1-Cyclohexyl-3-azetidinyl)oxy]-3-pyridine carboxylate | HCID 23696211 | 86% |
반응 단계
A solution of 105 g (0.68 mole) of 1-cyclohexyl-3-azetidinol and 106 g (0.68 mole) of 2-chloronicotinic acid in 400 ml of dry dimethylformamide was added at a rapid drop to 52 g (1.35 mole) of 60% sodium hydride/mineral oil suspended in 400 ml of dry dimethylformamide at 60° C. Mild exothermic reaction was noted. After stirring for 2 hr at 60° C., the mixture was filtered. The filter cake was washed with ethylacetate and dried at 80° C./2 mm to give 174 g (86%) of crude title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04705853 |
|---|
| 출처 데이터셋 | uspto-grants-1987_11 |
|---|
| ORD ID | ord-ce2ab8d714284f7c9e046ad64e1faa0b |
|---|
| 출처 메모 | uspto-grants-1987_11 |
|---|
