Dimethylamine → 1-Dimethylamino-3-methylamino-2-propanol hydrochloride

Dimethylamine 22.6 g, 40% solution (0.2 mole) was added dropwise to a solution of 16 ml of epichlorohydrin (0.2 mole) in 100 ml of methanol at 5° C. stirring in an ice bath. After two hours at 5° C. a chilled solution of 86 ml methylamine of 40% solution (1 mole) was poured into the reaction mixture. Stirring was continued in ice bath for one hour and then room temperature overnight. The solvents were evaporated and the clear oil was pumped under vacuum at 75° C. for 1.5 hr to give 28.23 g (~84% yield) of 1-dimethylamino-3-methylamino-2-propanol hydrochloride (I) as the main product.

1. stirringStirring
2. customfor one hour
3. customroom temperature overnight
4. customThe solvents were evaporated

ORD 기록

ord-421c2a810de34931a30522418740fddc

출처 데이터셋

uspto-grants-1987_11

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US04705853