Diketene → Acetoacetic acid N-[4-(6-oxo-1,4,5,6-tetrahydropyridazin-3yl)-phenyl]-amide

HRID 247366

반응식

HRID 247366 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:13][CH2:12][C:11](=[O:14])[NH:10][N:9]=2)=[CH:4][CH:3]=1.[CH2:15]=[C:16]1[O:20][C:18](=[O:19])[CH2:17]1>CN(C)C=O>[O:14]=[C:11]1[NH:10][N:9]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([NH:1][C:18](=[O:19])[CH2:17][C:16]([CH3:15])=[O:20])=[CH:7][CH:6]=2)[CH2:13][CH2:12]1

참가 물질

4

반응물 2

HCID 12661DiketeneHCID 6767506-(4-Aminophenyl)-4,5-dihydropyridazin-3(2H)-one

생성물 1

HCID 13646979Acetoacetic acid N-[4-(6-oxo-1,4,5,6-tetrahydropyridazin-3yl)-phenyl]-amide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

20 g (0.106 mole) of 3-(4-aminophenyl)-6-oxo-1,4,5,6-tetrahydropyridazine in 250 ml of dimethylformamide are stirred with 9.47 g (0.113 moles) of diketene for 12 hours at room temperature. After the mixture has been concentrated, the residue is boiled up with 100 ml of ethanol, and the product is filtered off after cooling.

후처리

  1. concentrationAfter the mixture has been concentrated
  2. filtrationthe product is filtered off
  3. temperatureafter cooling

출처 및 근거

ORD 기록
ord-06341a1303b7490f95e684614b1007ea
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04707479

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