2-Propanone, 1-nitro- → 4-(2-Benzylmercaptophenyl)-1,4-dihydro-2,6-dimethyl-5-nitropyridine-3-carboxylic acid N-[4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)-phenyl]-amide

HRID 247368노트

반응식

HRID 247368 반응식
[CH2:1]([S:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH:11]=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:17]([CH2:20][C:21](=O)[CH3:22])([O-:19])=[O:18].[O:24]=[C:25]1[NH:30][N:29]=[C:28]([C:31]2[CH:36]=[CH:35][C:34]([NH:37][C:38](=[O:43])/[CH:39]=[C:40](\[NH2:42])/[CH3:41])=[CH:33][CH:32]=2)[CH2:27][CH2:26]1>C(O)(C)C>[O:24]=[C:25]1[NH:30][N:29]=[C:28]([C:31]2[CH:32]=[CH:33][C:34]([NH:37][C:38]([C:39]3[CH:11]([C:10]4[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=4[S:8][CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[C:20]([N+:17]([O-:19])=[O:18])=[C:21]([CH3:22])[NH:42][C:40]=3[CH3:41])=[O:43])=[CH:35][CH:36]=2)[CH2:27][CH2:26]1

참가 물질

5

반응물 3

HCID 662962-Propanone, 1-nitro-HCID 111178092-(Benzylsulfanyl)benzaldehydeHCID 70353925HCID 70353925, 화합물

생성물 1

HCID 704356234-(2-Benzylmercaptophenyl)-1,4-dihydro-2,6-dimethyl-5-nitropyridine-3-carboxylic acid N-[4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)-phenyl]-amide

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

10 mmoles of 2-benzylmercaptobenzaldehyde, 15 mmoles of nitroacetone and 10 mmoles of 3-aminocrotonic acid N-[4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)-phenyl]-amide in 30 ml of isopropanol are heated at 60°-70° C. for 10 hours. The reaction mixture is concentrated and the residue is taken up in chloroform and chromatographed over silica gel using chloroform to which methanol is added. The product is recrystallized from isopropanol.

후처리

  1. concentrationThe reaction mixture is concentrated
  2. customchromatographed over silica gel
  3. additionis added
  4. customThe product is recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-2f217b0ecf554432a8b63ae406eeb837
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04707479

반응 노트

불러오는 중…