6-(4-methoxy-3-n-propoxyphenyl)-3[2H]pyridazinone → 6-[4-Methoxy-3-(3-methylbutoxy)phenyl]-3[2H]pyridazinone

HRID 247397노트

반응식

HRID 247397 반응식
CO[C:3]1[CH:8]=CC(C2C=CC(=O)NN=2)=C[C:4]=1OCCC.C(OC1C=C(C2C=CC(=O)NN=2)C=CC=1OC)C=C.[CH2:39]([O:41][C:42]1[CH:43]=[C:44]([C:50]2[CH:51]=[CH:52][C:53](=[O:56])[NH:54][N:55]=2)[CH:45]=[CH:46][C:47]=1[O:48][CH3:49])[CH3:40].C(OC1C=CC(C2C=CC(=O)NN=2)=CC=1OC)(C)C>>[CH3:49][O:48][C:47]1[CH:46]=[CH:45][C:44]([C:50]2[CH:51]=[CH:52][C:53](=[O:56])[NH:54][N:55]=2)=[CH:43][C:42]=1[O:41][CH2:39][CH2:40][CH:3]([CH3:8])[CH3:4]

참가 물질

5

반응물 4

HCID 201606206-(4-methoxy-3-n-propoxyphenyl)-3[2H]pyridazinoneHCID 201606216-(4-isopropoxy-3-methoxyphenyl)-3[2H]pyridazinoneHCID 201606486-(3-ethoxy-4-methoxyphenyl)-3[2H]pyridazinoneHCID 201606566-(3-allyloxy-4-methoxyphenyl)-3[2H]pyridazinone

생성물 1

HCID 201606366-[4-Methoxy-3-(3-methylbutoxy)phenyl]-3[2H]pyridazinone

실험 절차

The following are obtained analogously: 6-(4-methoxy-3-n-propoxyphenyl)-3[2H]pyridazinone, m.p. 196°, 17.5% of theory, 6-(3-allyloxy-4-methoxyphenyl)-3[2H]pyridazinone, m.p. 175°, 16.3% of theory, 6-(3-ethoxy-4-methoxyphenyl)-3[2H]pyridazinone, m.p. 171°, 15.1% of theory and 6-(4-isopropoxy-3-methoxyphenyl)-3[2H]pyridazinone, m.p. 200°, 26.4% of theory.

후처리

  1. customThe following are obtained analogously

출처 및 근거

ORD 기록
ord-2fef6eedab714224ae8fc447e0d2882a
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04707481

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