3,5-Dichlorobenzaldehyde → O-Methyl-3,5-dichlorobenzaldoxime

HRID 247408

반응식

HRID 247408 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:10])[CH:9]=1)[CH:5]=O.Cl.[CH3:12][O:13][NH2:14]>C(O)C.N1C=CC=CC=1>[CH3:12][O:13][N:14]=[CH:5][C:4]1[CH:3]=[C:2]([Cl:1])[CH:9]=[C:8]([Cl:10])[CH:7]=1

참가 물질

5

반응물 2

HCID 357463,5-DichlorobenzaldehydeHCID 521874O-Methylhydroxylamine hydrochloride

생성물 1

HCID 72726781O-Methyl-3,5-dichlorobenzaldoxime수율 94%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 1049Pyridine용매

실험 절차

A solution of 3,5-dichlorobenzaldehyde (0.0571 mol) and methoxyamine hydrochloride (0.0629 mol) in ethanol (50 ml) and pyridine (50 ml) was stirred 18 hours at room temperature. The reaction was concentrated and partitioned between methylene chloride and water. The organic phase was washed with 3N aqueous hydrogen chloride, dried over sodium sulfate and was concentrated to yield 10.9 g (94%) white solid, mp 53°.

후처리

  1. concentrationThe reaction was concentrated
  2. custompartitioned between methylene chloride and water
  3. washThe organic phase was washed with 3N aqueous hydrogen chloride
  4. dry with materialdried over sodium sulfate
  5. concentrationwas concentrated

출처 및 근거

ORD 기록
ord-9fa7e3ca066a4f54be725bc7e4f90633
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04707488

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