Diethyl Ether → 3-(3,5-Difluorophenyl)propyl Isothiocyanate
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][NH2:12])[CH:5]=[C:6]([F:8])[CH:7]=1.C(N(CC)CC)C.[C:20](Cl)(Cl)=[S:21].C(OCC)C>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][N:12]=[C:20]=[S:21])[CH:5]=[C:6]([F:8])[CH:7]=1참가 물질
6
실험 절차
A solution of 3-(3,5-difluorophenyl)propylamine (0.0327 mol) and triethylamine (0.072 mol) in tetrahydrofuran (20 ml) was added dropwise to a solution of thiophosgene (0.0392 mol) in tetrahydrofuran at 0°. The reaction was stirred 2 hours at room temperature then ethyl ether was added and the mixture filtered. The filtrate was concentrated and distilled (Kugelrohr) to yield 3.8 g (55%) of a yellow oil.
후처리
- filtrationthe mixture filtered
- concentrationThe filtrate was concentrated
- distillationdistilled (Kugelrohr)
출처 및 근거
- ORD 기록
- ord-b092461fe7c442fe86c3cea067b44f22
- 출처 데이터셋
- uspto-grants-1987_11
- 특허 번호
- US04707488
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