Pyridine → 1-Bromo-4-(chloromethyl)-2-methoxybenzene

HRID 247453노트

반응식

HRID 247453 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]O)=[CH:4][C:3]=1[O:10][CH3:11].N1C=CC=CC=1.S(Cl)([Cl:20])=O>C1(C)C=CC=CC=1.O>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][Cl:20])=[CH:4][C:3]=1[O:10][CH3:11]

참가 물질

6

반응물 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 13551345(4-Bromo-3-methoxyphenyl)-methanol

생성물 1

HCID 201606681-Bromo-4-(chloromethyl)-2-methoxybenzene

시약·촉매·용매 2

HCID 962Water용매HCID 1140Toluene용매

실험 절차

4-Bromo-3-methoxybenzyl alcohol (21.7 g, 0.1 m) dissolved in toluene (200 ml) containing pyridine (11.8 g, 0.15 m) is stirred at 5° and treated wiih thionyl chloride (23.8 g, 0.2 m). The mixture is stirred, diluted with water and the organic layer washed with dilute hydrochloric acid, dried and concentrated in vacuo to give 4-bromo-3-methoxybenzyl chloride.

후처리

  1. stirringThe mixture is stirred
  2. washthe organic layer washed with dilute hydrochloric acid
  3. customdried
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-2b5d87918c484b3b8c5eb1f62f3d0379
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04707483

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