Methanol → Benzeneacetic acid, alpha-ethyl-, methyl ester

HRID 247456

반응식

HRID 247456 반응식
[C:1]1([CH:7]([CH2:11][CH3:12])[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)(Cl)=O.[CH3:17]O>C(OCC)C>[C:1]1([CH:7]([CH2:11][CH3:12])[C:8]([O:10][CH3:17])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 70122-Phenylbutyric AcidHCID 24386Thionyl Chloride

생성물 1

HCID 102780Benzeneacetic acid, alpha-ethyl-, methyl ester

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To 102 g. of 2-phenylbutyric acid dissolved in 1 liter of methanol was added 2 ml of thionyl chloride. The solution was allowed to stand at room temperature overnight. The solvent was removed in vacuo to yield an oil which was dissolved in diethyl ether, washed successively with dilute sodium bicarbonate solution and saturated sodium chloride solution, dried over anhydrous potassium carbonate, and concentrated in vacuo. Distillation yielded 101 g of the title compound as a water-white oil, b.p. 62°-65°/0.5 mm, having the following elemental analysis:

후처리

  1. customThe solvent was removed in vacuo
  2. customto yield an oil which
  3. washwashed successively with dilute sodium bicarbonate solution and saturated sodium chloride solution
  4. dry with materialdried over anhydrous potassium carbonate
  5. concentrationconcentrated in vacuo
  6. distillationDistillation

출처 및 근거

ORD 기록
ord-6cb8aa009e3d4806be2a7f4eb9928fba
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04707499

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