[OH:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.Cl[CH2:20][CH2:21][CH2:22][OH:23]>CN(C)C=O.C[O-].[Na+]>[OH:23][CH2:22][CH2:21][CH2:20][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][CH:9]=2)=[O:7])=[CH:17][CH:18]=15 g of 3-(p-hydroxybenzoyl) indole were dissolved in 50 ml of dimethylformamide containing 2.28 g of sodium methoxide. 4.0 g of 3-chloropropanol was added to the solution followed by stirring at 110° C. in oil bath for 3 hours. After cooling, the solution was concentrated and extracted with 100 ml of ethyl acetate and 50 ml of water. The organic layer obtained was concentrated, and then the residue was purified by column chromatography on silica gel. Crude product was recrystallized from ethyl acetate to give 3-[p-(3-hydroxypropoxy)benzoyl]indole (compound 23) in the form of white needle crystals. (Yield: 30.5%).
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