Hydrogen chloride-ethyl acetate → HCID 178507732, 화합물

HRID 24758노트

반응식

HRID 24758 반응식
C(OC([NH:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15]/[C:16](=[C:23]2\[C:24](=[O:32])[NH:25][C:26]3[C:31]\2=[CH:30][CH:29]=[CH:28][CH:27]=3)/[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:11][CH:10]=1)=O)(C)(C)C.C(OCC)(=O)C.Cl>ClCCl.CCOCC>[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15]/[C:16](=[C:23]2\[C:24](=[O:32])[NH:25][C:26]3[C:31]\2=[CH:30][CH:29]=[CH:28][CH:27]=3)/[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[CH:11][CH:10]=1

참가 물질

5

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178452787HCID 178452787, 화합물

생성물 1

HCID 178507732HCID 178507732, 화합물

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

반응 조건

온도
40 °C

실험 절차

1.7 g (4 mmol) of (Z)-3-[1-(4-tert.butoxycarbonylamino-phenylamino)-1-phenyl-methylidene]-2-indolinone are suspended in 15 ml of dichloromethane and after the addition of 35 ml of ethyl acetate/hydrogen chloride for 18 hours at ambient temperature and stirred for 2 hours at 40° C. After cooling the mixture is diluted with ether and the precipitate is suction filtered. The residue is divided between sodium chloride solution and methylene chloride, the organic extracts are dried and concentrated by evaporation.

후처리

  1. temperatureAfter cooling the mixture
  2. filtrationfiltered
  3. customthe organic extracts are dried
  4. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-8fa7049170a2422889d0449785b89eb9
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855710B2

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