Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1-methyl-pyrrolidine-2,5-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 2,6-Di-tert-butylphenol | HCID 31405 | — |
| 반응물 | N-Methylmaleimide | HCID 70261 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | tert-Butanol | HCID 6386 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | Heptane | HCID 8900 | — |
| 생성물 | 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1-methyl-pyrrolidine-2,5-dione | HCID 14148374 | 9.5% |
반응 단계
This compound is prepared by the procedure of Example 1 from 2.40 g (0.1 mol) of sodium hydride, 20.63 g (0.1 mol) of 2,6-di-tert-butylphenol, and 11.11 g (0.1 mol) of N-methylmaleimide in tert-butyl alcohol. The residue is recrystallized from petroleum ether to give 13.2 g (42%) of crude product. The analytical sample is prepared by flash chromatography (1:1 heptane:ethyl acetate eluent) followed by trituration with a mixture of heptane and toluene to give 3.0 g of a white solid: mp 164°-166° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04709050 |
| 출처 데이터셋 | uspto-grants-1987_11 |
| ORD ID | ord-53eea7b7a4c14ee1888689b3797f1755 |
| 출처 메모 | uspto-grants-1987_11 |