Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 3-(dimethylamino)acrylate → Methyl 4-(2,3-dichlorophenyl)-1H-pyrrole-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 3-(dimethylamino)acrylate | HCID 566587 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | Ethanone, 2-amino-1-(2,3-dichlorophenyl)-, hydrochloride | HCID 22151845 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Methyl 4-(2,3-dichlorophenyl)-1H-pyrrole-3-carboxylate | HCID 15087831 | — |
반응 단계
10.7 g of 2,3-dichlorophenacylamine hydrochloride and 6 g of methyl 3-dimethylaminoacrylate are heated for 2 hours under reflux in 120 ml of ethanol. Then a solution of 4 g of sodium ethylate in 40 ml of ethanol is added dropwise and the reaction mixture is heated for another hour under reflux. The reaction mixture is then concentrated by evaporation and the oily residue is purified by column chromatography (silica gel; elution with a 3:1 mixture of toluene/ethyl acetate. Melting point: 205°-206° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04709053 |
| 출처 데이터셋 | uspto-grants-1987_11 |
| ORD ID | ord-750983bedfe549e1acd00975d504a47a |
| 출처 메모 | uspto-grants-1987_11 |