Dichloromethane → (S)-4-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-2-methyl-1,2-epoxy-butane

HRID 247637노트

반응식

HRID 247637 반응식
[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[C:7]([CH3:10])[C:6]([O:11][CH3:12])=[C:5]([CH3:13])[C:4]=1[CH2:14][CH2:15][C@:16]([CH3:30])([OH:29])[CH2:17]OS(C1C=CC=CC=1C)(=O)=O.[OH-].[K+].C(Cl)Cl>C(O)C>[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[C:7]([CH3:10])[C:6]([O:11][CH3:12])=[C:5]([CH3:13])[C:4]=1[CH2:14][CH2:15][C@:16]1([CH3:30])[O:29][CH2:17]1

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 14797Potassium HydroxideHCID 86740735(S)-4-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-2-methyl-1-toluenesulphonyloxy-2-butanol

생성물 1

HCID 18602184(S)-4-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-2-methyl-1,2-epoxy-butane수율 98%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

177 mg of (S)-4-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-2-methyl-1-toluylsulphonyloxy-2-butanol were dissolved in 1 ml of ethanol and the solution was treated with 0.3 ml of alcoholic potassium hydroxide solution (1.5N). The mixture was left to stand at room temperature for 10 minutes, 30 ml of methylene chloride were then added and the resulting mixture was dried over sodium sulphate and concentrated. There were obtained 105 mg of (S)-4-(2',5'-dimethoxy-3',4',6'-trimethylphenyl)-2-methyl-1,2-epoxybutane. M.p. 47°-48° C.

후처리

  1. waitThe mixture was left
  2. dry with materialthe resulting mixture was dried over sodium sulphate
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-bbca149180f5440f9594ff64217482ad
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04709055

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