Acetone → N-(3,5-dimethyl-2-hydroxybenzyl)acrylamide

HRID 247654

반응식

HRID 247654 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[OH:9].[CH2:10]([NH:12][C:13](=[O:16])[CH:14]=[CH2:15])O.CC(C)=O>C1(C)C=CC(S(O)(=O)=O)=CC=1.O>[CH3:1][C:2]1[C:3]([OH:9])=[C:4]([CH:5]=[C:6]([CH3:8])[CH:7]=1)[CH2:10][NH:12][C:13](=[O:16])[CH:14]=[CH2:15]

참가 물질

6

반응물 3

HCID 180AcetoneHCID 77712,4-DimethylphenolHCID 13543N-Methylolacrylamide

생성물 1

HCID 14008274N-(3,5-dimethyl-2-hydroxybenzyl)acrylamide수율 84.9%

시약·촉매·용매 2

HCID 6101p-Toluenesulfonic acid촉매HCID 962Water용매

실험 절차

A flask equipped with a condenser and a stirrer was charged with 122 g of 2,4-dimethylphenol, 101 g of N-methylolacrylamide, 1.80 g of p-toluenesulfonic acid and 100 ml of acetone, and the mixture was reacted at 60° C. for 60 minutes with stirring. The obtained reaction mixture was poured into excess water to separate an organic layer. The organic layer was dissolved in 200 ml of methylene chloride, which was washed with three 100 ml portions of water to give 174 g of N-(3,5-dimethyl-2-hydroxybenzyl)acrylamide.

후처리

  1. customA flask equipped with a condenser and a stirrer
  2. customthe mixture was reacted at 60° C. for 60 minutes
  3. customThe obtained reaction mixture
  4. customto separate an organic layer
  5. dissolutionThe organic layer was dissolved in 200 ml of methylene chloride
  6. washwhich was washed with three 100 ml portions of water

출처 및 근거

ORD 기록
ord-855147608f414415ae4a431787888b5b
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04709062

연결된 노트

불러오는 중…