Sulfuric Acid → HCID 13488963, 화합물

HRID 247769

반응식

HRID 247769 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:11])[CH3:10])=[C:4]([F:12])[CH:3]=1.[S:13](=O)(=[O:16])([OH:15])[OH:14]>>[C:9]([NH:8][C:5]1[C:4]([F:12])=[CH:3][C:2]([Br:1])=[C:7]([S:13]([OH:16])(=[O:15])=[O:14])[CH:6]=1)(=[O:11])[CH3:10]

참가 물질

3

반응물 2

HCID 1118Sulfuric Acid2회HCID 67593N-(4-bromo-2-fluorophenyl)acetamide

생성물 1

HCID 13488963HCID 13488963, 화합물

반응 조건

온도
20 °C

실험 절차

N-(4-Bromo-2-fluorophenyl)acetamide (173.2 g) was suspended in conc. sulfuric acid (80 ml), and 60% fuming sulfuric acid (340 ml) was dropwise added thereto at 10 to 20° C., followed by stirring at 20° C. for 2 hours. The reaction mixture was dropwise added to ice water (500 g) at 10° to 20° C., and the precipitated crystals were collected by filtration, washed with cold water (400 ml) and dried under reduced pressure to give 175.8 g of 5-(N-acetylamino)-2-bromo-4-fluorobenzenesulfonic acid. M.P., more than 300° C.

후처리

  1. customat 10 to 20° C.
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with cold water (400 ml)
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-02b16acf379a4702aa27d3b8f8922816
출처 데이터셋
uspto-grants-1987_11
특허 번호
US04709049

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