1-Chloroethyl chloroformate → HCID 178485767, 화합물

HRID 24778

반응식

HRID 24778 반응식
C([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]([N:17]([C:19]2[CH:24]=[CH:23][C:22]([NH:25]/[C:26](=[C:33]3\[C:34](=[O:42])[NH:35][C:36]4[C:41]\3=[CH:40][CH:39]=[CH:38][CH:37]=4)/[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:21][CH:20]=2)[CH3:18])=[O:16])[CH2:10][CH2:9]1)C1C=CC=CC=1.[Cl:43]C(OC(Cl)C)=O>ClCCl>[ClH:43].[ClH:43].[N:11]1([CH2:14][C:15]([N:17]([C:19]2[CH:24]=[CH:23][C:22]([NH:25]/[C:26](=[C:33]3\[C:34](=[O:42])[NH:35][C:36]4[C:41]\3=[CH:40][CH:39]=[CH:38][CH:37]=4)/[C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:21][CH:20]=2)[CH3:18])=[O:16])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

참가 물질

4

반응물 2

HCID 5213051-Chloroethyl chloroformateHCID 178485769HCID 178485769, 화합물

생성물 1

HCID 178485767HCID 178485767, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

390 mg (0.7 mmol) of (Z)-3-{1-[4-(N—(N-benzylpiperazinomethylcarbonyl)-N-methylamino)-phenylamino]-1-phenyl-methylidene}-2-indolinone are dissolved in 20 ml of dichloromethane and after the addition of 0.2 g (1.4 mmol) of 1-chloroethyl chloroformate heated for 30 minutes at ambient temperature and refluxed for 60 minutes. The solvent is concentrated by evaporation, the residue is combined with 10 ml of methanol and refluxed for 90 minutes. After 18 hours stirring at ambient temperature, the product is suction filtered, washed with methanol and dried.

후처리

  1. temperaturerefluxed for 60 minutes
  2. concentrationThe solvent is concentrated by evaporation
  3. temperaturerefluxed for 90 minutes
  4. filtrationfiltered
  5. washwashed with methanol
  6. customdried

출처 및 근거

ORD 기록
ord-1e02debe0c2c40d8bd1bb285536265c9
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855710B2

연결된 노트

불러오는 중…