참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Acetamide, N-[2,6-bis(1-methylethyl)phenyl]-2-bromo- | HCID 12149064 | — |
| 반응물 | Dibenzylphosphite | HCID 21904359 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Sodium dibenzylphosphite | HCID 23706462 | — |
반응 단계
A solution of sodium dibenzylphosphite is prepared by the addition of a 60% mineral oil dispersion of sodium hydride (0.4 g, 0.01 mol) to a solution of dibenzyl phosphite (2.62 g, 0.01 mol) in dry tetrahydrofuran (20 mL). To the resultant solution is added N-[2,6-bis(1-methylethyl)phenyl]-2-bromoacetamide (2.98 g, 0.01 mol) and the mixture is stirred at 50° C. overnight. The reaction mixture is filtered and concentrated. Flash chromatography and crystallization affords 1.4 g of the title compound; mp 117°-119° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05208224 |
|---|
| 출처 데이터셋 | uspto-grants-1993_05 |
|---|
| ORD ID | ord-a55b806b45ab4d79833bdc4756835658 |
|---|
| 출처 메모 | uspto-grants-1993_05 |
|---|
