Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diazomethane → methyl 1H-indole-4-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diazomethane | HCID 9550 | — |
| 반응물 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 반응물 | Indole-4-carboxylic acid | HCID 595229 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | methyl 1H-indole-4-carboxylate | HCID 2733668 | 98% |
반응 단계
To a solution of indole-4-carboxylic acid (506 mg, 3.14 mmol) dissolved in a mixture of methanol (5 mL) and diethyl ether (10 mL) was added ethereal diazomethane until disappearance of the starting acid was indicated by TLC. Magnesium sulfate was then added and the solution filtered and concentrated in vacuo. Flash chromatography on Merck silica gel (10 g) eluted with 2:1, chloroform:hexanes, followed by 10:1, chloroform: ether afforded the title compound (540 mg, 98%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05208235 |
| 출처 데이터셋 | uspto-grants-1993_05 |
| ORD ID | ord-f3eca2e7cd8b4af0b2f619fef1d40c9d |
| 출처 메모 | uspto-grants-1993_05 |