Acetic Acid → 4-Thiazolidinone, 5-[(2,3-dimethoxyphenyl)methylene]-2-thioxo-

HRID 247864

반응식

HRID 247864 반응식
[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=O.[S:13]1[CH2:19][C:17](=[O:18])[NH:16][C:14]1=[S:15].C([O-])(=O)C.[Na+].C(O)(=O)C>O>[CH3:1][O:2][C:3]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=[C:19]1[S:13][C:14](=[S:15])[NH:16][C:17]1=[O:18]

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 665812,3-DimethoxybenzaldehydeHCID 517045Sodium AcetateHCID 1201546Rhodanine

생성물 1

HCID 46021174-Thiazolidinone, 5-[(2,3-dimethoxyphenyl)methylene]-2-thioxo-수율 95.6%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 2,3-dimethoxybenzaldehyde (5.2 g, 30 mmoles), rhodanine (4.0 g, 29 mmoles), sodium acetate (8.4 g, 102 mmoles), and acetic acid (50 ml) is stirred under an inert atmosphere and heated to reflux. After 4 hours the mixture is stirred into water (250 ml) and the precipitate is filtered off, rinsed successively with water (3×), ethanol (2×), and ether (2×), and dried to afford the pure product (7.8 g), mp 268°-269° C.

후처리

  1. temperatureheated to reflux
  2. filtrationthe precipitate is filtered off
  3. washrinsed successively with water (3×), ethanol (2×), and ether (2×)
  4. customdried

출처 및 근거

ORD 기록
ord-2062fc42fbed44ee80bba714c5724e0e
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05208250

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