3-Bromo-4-hydroxybenzaldehyde → 5-[(3-Bromo-4-hydroxyphenyl)methylene]-2-thioxo-4-imidazolidinone

HRID 247872

반응식

HRID 247872 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[OH:10])[CH:5]=O.[NH:11]1[CH2:17][C:15](=[O:16])[NH:14][C:12]1=[S:13].C([O-])(=O)C.[Na+]>C(O)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:17]2[NH:11][C:12](=[S:13])[NH:14][C:15]2=[O:16])[CH:7]=[CH:8][C:9]=1[OH:10]

참가 물질

5

반응물 3

HCID 763083-Bromo-4-hydroxybenzaldehydeHCID 517045Sodium AcetateHCID 12740302-Thiohydantoin

생성물 1

HCID 38739105-[(3-Bromo-4-hydroxyphenyl)methylene]-2-thioxo-4-imidazolidinone수율 75.8%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Prepared according to the procedure described in Example 1 using 3-bromo-4-hydroxybenzaldehyde (3.1 g, 15 mmoles), 2-thiohydantoin (1.7 g, 15 mmoles), sodium acetate (4.5 g, 55 mmoles), and acetic acid (35 ml), to afford the pure product (3.4 g), mp 262° C. (dec).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-d8a5fba2efb349b8b653a4192d4719a7
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05208250

연결된 노트

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