Beta-Alanine → 5-[(3,5-Dimethoxy-4-hydroxyphenyl)methylene]-2,4-imidazolidinedione

반응식

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:12][CH3:13])[C:10]=1[OH:11])[CH:6]=O.[NH:14]1[CH2:20][C:18](=[O:19])[NH:17][C:15]1=[O:16].NCCC(O)=O>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:6]=[C:20]2[NH:14][C:15](=[O:16])[NH:17][C:18]2=[O:19])[CH:8]=[C:9]([O:12][CH3:13])[C:10]=1[OH:11]

참가 물질

반응물 3

HCID 239Beta-Alanine

HCID 8655Syringaldehyde

HCID 10006Hydantoin

생성물 1

HCID 40887335-[(3,5-Dimethoxy-4-hydroxyphenyl)methylene]-2,4-imidazolidinedione수율 75.7%

실험 절차

Prepared according to the procedure described in Example 90 using 3,5-dimethoxy-4-hydroxybenzaldehyde (5.6 g, 30 mmoles), hydantoin (3.0 g, 30 mmoles), and β-alanine (1.4 g, 16 mmoles), to afford the pure product (6.0 g), mp 296°-297° C.

후처리

customPrepared

출처 및 근거

ORD 기록: ord-3d660741385f46c6bdfea1d9d1bd8c27
출처 데이터셋: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05208250

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