Ammonium nitrate → 1-Acetyl-5-nitroindolin-2-one

HRID 24796

반응식

HRID 24796 반응식
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:13])(=[O:3])[CH3:2].[N+:14]([O-])([O-:16])=[O:15].[NH4+]>S(=O)(=O)(O)O>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:14]([O-:16])=[O:15])=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:13])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 22985Ammonium nitrateHCID 3237191-Acetylindolin-2-one

생성물 1

HCID 28393291-Acetyl-5-nitroindolin-2-one

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

17.5 g (0.10 mol) of 1-acetyl-2-indolinone are dissolved in 100 ml of conc. sulphuric acid and at −10° C. 8.8 g (0.11 mol) of ammonium nitrate are added batchwise and stirred for 15 minutes. The reaction is poured onto ice water, suction filtered and washed with water. The residue is distributed in ethyl acetate/water, the combined organic extracts are dried and concentrated by evaporation.

후처리

  1. additionThe reaction is poured onto ice water, suction
  2. filtrationfiltered
  3. washwashed with water
  4. customthe combined organic extracts are dried
  5. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-876a4116b49845fd9885779f56dd4f70
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855710B2

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