Water → p-Tetradecyloxyphenylacetic acid

HRID 247961

반응식

HRID 247961 반응식
C[O:2][C:3](=[O:26])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[CH:7][CH:6]=1.[OH-].[K+].O>C(O)C>[CH2:12]([O:11][C:8]1[CH:9]=[CH:10][C:5]([CH2:4][C:3]([OH:26])=[O:2])=[CH:6][CH:7]=1)[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

참가 물질

5

반응물 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 10316608[4-(Tetradecyloxy)phenyl]acetic acid methyl ester

생성물 1

HCID 10472964p-Tetradecyloxyphenylacetic acid수율 84.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The title compound is prepared by the procedure of Example 32 using 75 g of product from Example 51, 34.8 g of potassium hydroxide, 45 ml of water and 800 ml of ethyl alcohol. The residue is recrystallized from carbon tetrachloride/hexane to give 60.6 g of the desired product as white crystals.

후처리

  1. customThe residue is recrystallized from carbon tetrachloride/hexane

출처 및 근거

ORD 기록
ord-5b5faf5a834a4acba131ff2cbd95162f
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05208247

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