Methanol → Methyl 2-(3-fluoro-4-hydroxyphenyl)acetate

HRID 247969

반응식

HRID 247969 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[OH:8].[CH3:13]O.S(=O)(=O)(O)O>O>[CH3:13][O:11][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([F:1])[CH:3]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 680143-Fluoro-4-hydroxybenzeneacetic acid

생성물 1

HCID 10797559Methyl 2-(3-fluoro-4-hydroxyphenyl)acetate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 2.0 g of 3-fluoro-4-hydroxybenzeneacetic acid, 10 ml of methyl alcohol and 1 ml of concentrated sulfuric acid is heated at reflux temperature for 23.5 hours. The cooled solution is diluted with water and extracted with methylene chloride. The organic layer is washed with water, saturated sodium bicarbonate, water and saturated sodium chloride; dried and concentrated in vacuo. The residue is purified by column chromatography (silica gel:25% ethyl acetate/hexane) to give 1.9 g of the desired product.

후처리

  1. temperatureis heated
  2. temperatureat reflux temperature for 23.5 hours
  3. extractionextracted with methylene chloride
  4. washThe organic layer is washed with water, saturated sodium bicarbonate, water and saturated sodium chloride
  5. customdried
  6. concentrationconcentrated in vacuo
  7. customThe residue is purified by column chromatography (silica gel:25% ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-1b4c5b4238094374b404e5e81d4d6beb
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05208247

연결된 노트

불러오는 중…