Potassium Carbonate → HCID 54095197, 화합물

HRID 248012

반응식

HRID 248012 반응식
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([OH:11])[CH:5]=1.I[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[C:6]([O:11][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])[CH:5]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 202741-IodoheptaneHCID 287064Methyl 3,4-Dihydroxybenzoate

생성물 1

HCID 54095197HCID 54095197, 화합물수율 198.2%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

A mixture of 25 g of product from Example 102, 72.3 g of 1-iodoheptane, 61.65 g of potassium carbonate and 500 ml of 2-butanone is heated at reflux temperature for 44 hours. The cooled reaction mixture is filtered and concentrated in vacuo. The oily residue is purified by chromatography (silica gel: 10% ethyl acetate/hexane) to give 53.7 g of the desired product.

후처리

  1. temperatureis heated
  2. temperatureat reflux temperature for 44 hours
  3. customThe cooled reaction mixture
  4. filtrationis filtered
  5. concentrationconcentrated in vacuo
  6. customThe oily residue is purified by chromatography (silica gel: 10% ethyl acetate/hexane)

출처 및 근거

ORD 기록
ord-6aa4604a96724dc7be7271e866ed0eb3
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05208247

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