Ethanol → HCID 19015379, 화합물

HRID 248028노트

반응식

HRID 248028 반응식
C[O:2][C:3](=[O:25])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])=[C:6]([C:21]([CH3:24])([CH3:23])[CH3:22])[CH:5]=1.[OH-].[K+].CO.C(O)C>O>[CH2:11]([O:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:25])=[O:2])=[CH:5][C:6]=1[C:21]([CH3:22])([CH3:24])[CH3:23])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20]

참가 물질

6

반응물 4

HCID 702EthanolHCID 887MethanolHCID 14797Potassium HydroxideHCID 539263074-(Decyloxy)-3-(1,1-dimethylethyl)benzoic acid methyl ester

생성물 1

HCID 19015379HCID 19015379, 화합물수율 90.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 15.0 g of product from Example 130, 7.24 g of potassium hydroxide, 100 ml methyl alcohol, 40 ml ethyl alcohol and 10 ml of water is heated at reflux temperature for 18 hours. The reaction is cooled to room temperature, made acidic to pH 2, concentrated in vacuo, swirled with water and the solid collected. The solid residue is washed with water and dried in a vacuum oven to give 13 g of the desired product as colorless needles.

후처리

  1. temperatureis heated
  2. temperatureat reflux temperature for 18 hours
  3. concentrationconcentrated in vacuo
  4. customthe solid collected
  5. washThe solid residue is washed with water
  6. customdried in a vacuum oven

출처 및 근거

ORD 기록
ord-4b8c05b220b94513880905fce8c955b2
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05208247

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