3-Aminobenzonitrile → HCID 178509847, 화합물

HRID 24804

반응식

HRID 24804 반응식
C([N:9]1[C:17]2[C:12](=[CH:13][C:14]([N+:18]([O-:20])=[O:19])=[CH:15][CH:16]=2)[C:11](=[C:21](O)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:10]1=[O:29])(=O)C1C=CC=CC=1.[NH2:30][C:31]1[CH:32]=[C:33]([CH:36]=[CH:37][CH:38]=1)[C:34]#[N:35]>CN(C=O)C>[C:34]([C:33]1[CH:32]=[C:31]([NH:30]/[C:21](=[C:11]2\[C:10](=[O:29])[NH:9][C:17]3[C:12]\2=[CH:13][C:14]([N+:18]([O-:20])=[O:19])=[CH:15][CH:16]=3)/[C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:38]=[CH:37][CH:36]=1)#[N:35]

참가 물질

4

반응물 2

HCID 167023-AminobenzonitrileHCID 178516550HCID 178516550, 화합물

생성물 1

HCID 178509847HCID 178509847, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2 g (5.2 mmol) of 1-benzoyl-3-(1-hydroxy-1-phenyl-methylidene)-5-nitro-2-indolinone and 1.8 g (16 mmol) of 3-aminobenzonitrile are stirred in DMF for 70 hours at ambient temperature. Then the reaction solution is extracted with ether, the organic phase is washed with water and dried over sodium sulphate. After removal of the solvent in vacuo the residue is chromatographed on silica gel (dichloromethane/methanol=50:1).

후처리

  1. extractionThen the reaction solution is extracted with ether
  2. washthe organic phase is washed with water
  3. dry with materialdried over sodium sulphate
  4. customAfter removal of the solvent in vacuo the residue
  5. customis chromatographed on silica gel (dichloromethane/methanol=50:1)

출처 및 근거

ORD 기록
ord-bdb4ef81648c47fd8675561909d34a08
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06855710B2

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