4-(Trifluoromethyl)phenol → HCID 178521560, 화합물

HRID 248303

반응식

HRID 248303 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1>[Rh].C(O)C>[F:1][C:2]([F:10])([F:11])[C@H:3]1[CH2:4][CH2:5][C@H:6]([OH:9])[CH2:7][CH2:8]1

참가 물질

4

반응물 1

HCID 678744-(Trifluoromethyl)phenol

생성물 1

HCID 178521560HCID 178521560, 화합물

시약·촉매·용매 2

HCID 23948Rhodium촉매HCID 702Ethanol용매

실험 절차

A mixture of 0.3 mol of 4-trifluoromethylphenol, 1000 ml of ethanol and 20 g of rhodium/activated charcoal (5%) is hydrogenated for 2 hours at a pressure of 5 bar and a temperature of 60° C. Removal of the solid components by filtration and removal of the solvent by distillation give the cyclohexanol as a cis/trans mixture (30%/70%). From this, the pure trans-compound is obtained by heating with aluminium triisopropylate in toluene in the presence of 3,3-dimethyl-2-butanone and subsequent recrystallization.

후처리

  1. customa temperature of 60° C
  2. customRemoval of the solid components
  3. filtrationby filtration and removal of the solvent
  4. distillationby distillation

출처 및 근거

ORD 기록
ord-866de225724b4b2bbc71ba06737524c5
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05209868

연결된 노트

불러오는 중…