HCID 15670106, 화합물 → 4-[(5-Chloro-2-methoxyphenoxy)methyl]-1-piperidinepropanamine hydrochloride

HRID 248346노트

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HRID 248346 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:39][CH3:40])=[C:6]([CH:38]=1)[O:7][CH2:8][CH:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:11][CH2:10]1>CO>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:39][CH3:40])=[C:6]([CH:38]=1)[O:7][CH2:8][CH:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH2:17][NH2:18])[CH2:13][CH2:14]1

참가 물질

3

반응물 1

HCID 15670106HCID 15670106, 화합물

생성물 1

HCID 197633664-[(5-Chloro-2-methoxyphenoxy)methyl]-1-piperidinepropanamine hydrochloride수율 84.9%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
0 °C

실험 절차

9.5 g (0.017 mol) of 4-[(5-chloro-2-methoxyphenoxy)methyl]-N-(triphenylmethyl)-1-piperidinepropanamine are suspended in 215 ml of methanol. The reaction mixture is cooled to 0° C. and gaseous hydrochloric acid is bubbled in. The reaction mixture is allowed to return to room temperature and is evaporated to dryness, and the product obtained is recrystallised in an MeOH/AcOEt (50 ml:150 ml) mixture. Yield: 84.9%, M.p. 153°-157° C.

후처리

  1. customgaseous hydrochloric acid is bubbled in
  2. customto return to room temperature
  3. customis evaporated to dryness
  4. customthe product obtained
  5. customis recrystallised in an MeOH/AcOEt (50 ml:150 ml) mixture

출처 및 근거

ORD 기록
ord-9d9b43bfd5b548ac919601e45d9f3a41
출처 데이터셋
uspto-grants-1993_05
특허 번호
US05210086

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