Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 248347생성일: 2026년 10월 25일
Water → 4-[(4,5-Difluoro-2-methoxyphenoxy)methyl]-N-(triphenylmethyl)-1-piperidineethanamine
https://huagongshe.com/reaction/248347
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | (2-Bromoethyl)tritylamine | HCID 15718287 | — |
| 반응물 | HCID 19763367 | HCID 19763367 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-[(4,5-Difluoro-2-methoxyphenoxy)methyl]-N-(triphenylmethyl)-1-piperidineethanamine | HCID 19763385 | 41.5% |
반응 단계
5.88 g (0.020 mol) of 4-[(4,5-difluoro-2-methoxyphenoxy)methyl]piperidine hydrochloride, 7.7 g (0.021 mol) of 2-bromo-N-(triphenylmethyl)ethylamine and 6.91 g (0.050 mol) of K2CO3 in 40 ml of DMF are reacted. The reaction mixture is heated to 90° C. for 8 hours. It is cooled to room temperature, poured into 500 ml of water and extracted 3 times with ethyl acetate. The organic phases are combined, washed with water, dried over MgSO4 and filtered, and the solvent is evaporated off under reduced pressure. The product is obtained in the form of an oil after chromatography. Yield: 41.5%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05210086 |
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| 출처 데이터셋 | uspto-grants-1993_05 |
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| ORD ID | ord-d32e64f01da745f7a4d7dbc8a579c938 |
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| 출처 메모 | uspto-grants-1993_05 |
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