Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethyl orthovalerate → 2-butyl-1H-thieno[3,4-d]imidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethyl orthovalerate | HCID 83755 | — |
| 반응물 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 반응물 | Thiophene-3,4-diamine | HCID 643216 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-butyl-1H-thieno[3,4-d]imidazole | HCID 19370634 | — |
반응 단계
To a solution of 3,4-diaminothiophene (156 mg) in ethanol (10 ml) was added trimethyl orthovalerate (0.29 ml) and pyridinium p-toluenesulfonate (4 mg). The mixture was refluxed for one hour and concentrated in vacuo. The residue was purified by preparative thin layer chromatography on silica gel developed by ethyl acetate to give 2-butyl-1H-thieno[3,4-d]imidazole (155 mg) as crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05210092 |
| 출처 데이터셋 | uspto-grants-1993_05 |
| ORD ID | ord-354f919044724ce2b749849551db4a26 |
| 출처 메모 | uspto-grants-1993_05 |