참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Trifluoroacetate | HCID 517019 | — |
| 반응물 | 1-(4-Methylphenyl)-4-bromo-2-cyanopyrrole | HCID 18956250 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 1-(4-Methylphenyl)-4-trifluoromethylpyrrole-2-carbonitrile | HCID 19759270 | 27.9% |
반응 단계
A mixture of 4-bromo-1-(4-methylphenyl)pyrrole-2-carbonitrile (3.66 g), sodium trifluoroacetate (7.62 g), cuprous iodide (5.34 g) and N-methylpyrrolidone (40 ml) was stirred at 200° C. under a nitrogen atmosphere for 11 hours. The mixture was filtered. The filtrate was poured into water and extracted with ethyl acetate twice. The combined organic layer was dried over magnesium sulfate and evaporated in vacuo. The residue was purified by silica gel column chromatography to afford 1-(4-methylphenyl)-4-trifluoromethylpyrrole-2-carbonitrile (0.98 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US05210092 |
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| 출처 데이터셋 | uspto-grants-1993_05 |
|---|
| ORD ID | ord-5d9592eed04d4b8b9906eed4eb778fa5 |
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| 출처 메모 | uspto-grants-1993_05 |
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